We have listed vaccine ingredients (substances that appear in the final vaccine product), process ingredients (substances used to create the vaccine that may or may not appear in the final vaccine product), and growth mediums (the substances vaccines are grown in) for vaccines approved by the Food & Drug Administration (FDA) and commonly recommended by the Centers for Disease Control (CDC.) Controversial products used to make vaccines: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains.
Though not listed, each vaccine contains strains of the virus being vaccinated against. Each vaccine entry links to the manufacturer's package insert that contains information about dosage, ingredient quantity, and how the vaccine is made. Some vaccines, like influenza vaccines, are modified frequently and you may wish to consult the package inserts online and your doctor for the most current information. |
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|
| I. VACCINES AND INGREDIENTS |
1. Adenovirus
2. Anthrax
3. BCG (tuberculosis)
4. Cholera5. DT (diphtheria & tetanus)
6. DTap (diphtheria, tetanus, & pertussis)
7. DTap-IPV (diphtheria, tetanus, pertussis, & polio)
8. DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio)
9. DTap-IPV/Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B)
10. Hib (haemophilus influenzae type B)
11. Hib/Hep B (haemophilus influenzae type B & hepatitis B)
12. Hep A (hepatitis A)
13. Hep B (hepatitis B)
14. Hep A/Hep B (hepatitis A & hepatitis B)
15. HPV (human papillomavirus)
16. Influenza A (H1N1) (swine flu)17. Influenza A (H5N1) (bird flu) | 18. Influenza A & B 19. Japanese Encephalitis
20. Meningococcal
21. Measles
22. MMR (measles, mumps, & rubella)
23. Pneumococcal
24. Polio
25. Rabies
26. Rotavirus
27. Rubella
28. Smallpox
29. TD (tetanus & diphtheria)
30. Tdap (tetanus, diphtheria, & pertussis)
31. Typhoid
32. Varicella (chickenpox)
33. Yellow Fever
34. Zoster (shingles) |
|
| 1. Adenovirus Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Adenovirus Type 4 and Type 7 Vaccine, Live, Oral |
| -- |
|
| Barr Labs/Teva Pharmaceuticals (under contract with US Army) |
| Apr. 2014 |
| human-diploid fibroblast cell cultures (WI-38), Dulbecco's Modified Eagle's Medium, fetal bovine serum, sodium bicarbonate | sucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro-crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin, monosodium glutamate |
|
| 2. Anthrax Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Emergent Biosolutions |
| Nov. 2015 |
| amino acids, vitamins, inorganic salts and sugars | aluminum hydroxide, benzethonium chloride, formaldehyde, proteins (including 83kDa protective antigen) |
|
3. BCG Vaccine
(tuberculosis)
|
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Organon Teknika Corp. |
| Feb. 2009 |
| glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate | lactose, saline |
|
4. Cholera Vaccine
(tuberculosis) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Pax Vax Bermuda Ltd. |
| June 2016 |
| casamino acids, yeast extract, mineral salts, anti-foaming agent | ascorbic acid, Hy-Case SF (hydrolyzed casein), sodium chloride, sucrose, dried lactose, sodium bicarbonate, sodium carbonate |
|
5. DT Vaccine
(diphtheria & tetanus) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Diphtheria and Tetanus Toxoids Adsorbed |
| -- |
|
| Sanofi Pasteur, Ltd. |
| June 2013 |
| peptone, bovine extract, modified Mueller and Miller medium, aluminum phosphate, isotonic sodium chloride solution, casein, cysteine, dextrose, uracil, inorganic salts, vitamins | aluminum phosphate, formaldehyde |
|
6. DTap Vaccine
(diphtheria, tetanus, & pertussis) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed |
| Daptacel |
|
| Sanofi Pasteur, Ltd. |
| 2013 |
| Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), casamino acids, dimethyl-beta-cyclodextrin, ammonium sulfate, aluminum phosphate, glutaraldehyde, formaldehyde | aluminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed |
| Infanrix |
|
| GlaxoSmithKline Biologicals |
| 2013 |
| formaldehyde, glutaraldehyde, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, aluminum hydroxide | aluminum hydroxide, polysorbate 80, sodium chloride, formaldehyde |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed |
| Tripedia* |
*This vaccine has been discontinued. |
| Sanofi Pasteur, Inc. |
| Dec. 2005 |
| sodium phosphate, peptone-based medium, bovine extract (US sourced), formaldehyde, ammonium sulfate, aluminum potassium sulfate, modified Mueller and Miller medium, modified Stainer-Scholte medium, isotonic sodium, chloride solution, sodium phosphate | thimerosal, gelatin, polysorbate 80(Tween 80), formaldehyde, aluminum |
|
7. DTap-IPV Vaccine
(diphtheria, tetanus, pertussis, & polio) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine |
| Kinrix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| formaldehyde, glutaraldehyde, aluminum hydroxide, Vero cells, calf serum, lactalbumin hydrolysate, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium | polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, aluminum hydroxide, sodium chloride, formaldehyde |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine |
| Quadracel |
|
| modified Mueller's growth medium, ammonium sulfate, modified Mueller-Miller casamino acid medium(without beef heart infusion), aluminum phosphate, modified Stainer-Scholte medium (added casamino acids and dimethyl-beta-cyclodextrin), glutaraldehyde, formaldehyde, MRC-5 cells(with added Medium 199 without calf serum) | aluminum phosphate, 2-phenoxyethanol, water, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, polymyxin B sulfate |
|
8. DTap-HepB-IPV Vaccine
(diphtheria, tetanus, pertussis, hepatitis B, & polio) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Combined |
| Pediarix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, calf serum, Fenton medium(containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero cells | polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, yeast protein, aluminum salts, sodium chloride, formaldehyde |
|
9. DTap-IPV/Hib Vaccine
(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine |
| Pentacel |
|
| Sanofi Pasteur, Inc. |
| 2013 |
| aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, modified Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), modified Stainer-Scholte medium (with added casamino acids, dimethyl-beta-cyclodextrin), MRC-5 cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, water, Medium 199 (without calf serum) | polysorbate 80, bovine serum albumin, neomycin, sucrose, glutaraldehyde, polymyxin B sulfate, aluminum phosphate, formaldehyde, 2-phenoxyethanol |
|
10. Hib Vaccine
(haemophilus influenzae type B) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) |
| ActHIB |
|
| Sanofi Pasteur, Inc. |
| May 2016 |
| ammonium sulfate, Modified Mueller and Miller medium, saline diluent, formaldehyde, casein derivatives | sucrose, purified capsular polysaccharide |
| Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) |
| Hiberix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| formaldehyde, synthetic medium, semi-synthetic medium, saline diluent, lactose | lactose, sodium chloride, formaldehyde, purified capsular polysaccharide |
| Haemophilus B Conjugate Vaccine (Meningococcal Protein Conjugate) |
| Liquid PedvaxHIB |
|
| Merck Sharp & Dohme Corp. |
| Dec. 2010 |
| complex fermentation media, ethanol | amorphous aluminum hydroxyphosphate sulfate, sodium chloride |
|
11. Hib/Hep B Vaccine
(haemophilus influenzae type B & hepatitis B) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Haemophilus b Conjugate (Meningococcal Protein Conjugate) and Hepatitis B (Recombinant) Vaccine |
| COMVAX* |
*This vaccine has been discontinued. |
| Merck & Co., Inc. |
| Dec. 2010 |
| yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium borate | aluminum hydroxyphosphate sulphate, sodium chloride, formaldehyde |
|
12. Hep A Vaccine
(hepatitis A) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Hepatitis A Vaccine, Inactivated |
| Havrix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| MRC-5 cells | aluminum hydroxide, amino acid supplement, polysorbate 20, formaldehyde, neomycin sulfate, phosphate buffered saline, MRC-5 cellular proteins, aminoglycoside antibiotic |
| Hepatitis A Vaccine, Inactivated |
| VAQTA |
|
| Merck & Co., Inc. |
| Dec. 2010 |
| amorphous aluminumhydroxyphosphate sulfate, formaldehyde, neomycin, MRC-5 fibroblasts | bovine albumin, sodium borate, formaldehyde, non-viral proteins, sodium chloride, neomycin |
|
13. Hep B Vaccine
(hepatitis B) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| GlaxoSmithKline Biologicals |
| 2016 |
|
| aluminum hydroxide, yeast protein, phosphate buffers, sodium chloride, sodium dihydrogen, phosphate dihydrate |
|
|
| yeast protein, soy peptone, dextrose, amino acids, mineral salts, alum (potassium aluminum sulfate), amorphous aluminum hydroxyphosphate sulfate, formaldehyde | formaldehyde, yeast protein, aluminum |
|
14. Hep A/Hep B Vaccine
(hepatitis A & hepatitis B) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine |
| Twinrix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| yeast protein, MRC-5 cells, formaldehyde, aluminum salts | neomycin sulfate, MRC-5 cell proteins, formaldehyde, yeast protein, water, aluminum phosphate, aluminum hydroxide, amino acids, sodium chloride, phosphate buffer, polysorbate 20 |
|
15. HPV Vaccine
(human papillomavirus) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant |
| Cervarix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| vitamins, amino acids, lipids, mineral salts, aluminum (as hydroxide salt), sodium dihydrogen phosphate dihydrate, sodium chloride, water | insect cell and viral protein, sodium chloride, aluminum hydroxide, bacterial cell protein, sodium dihydrogen phosphate |
| Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant |
| Gardasil |
|
| yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, aluminum-containing adjuvant | L-histidine, polysorbate 80, sodium borate, amorphous aluminum hydroxyphosphate sulfate adjuvant, sodium chloride, yeast protein, water |
| Human Papillomavirus 9-valent Vaccine, Recombinant |
| Gardasil 9 |
|
| vitamins, amino acids, mineral salts, carbohydrates, yeast cells, aluminum-containing adjuvant (Amorphous Aluminum Hydroxyphosphate Sufate) | aluminum (Amorphous Aluminum Hydroxyphosphate Sulfate, sodium chloride, L-histidine, polysorbate 80, sodium borate, yeast protein, water |
|
16. Influenza A (H1N1) Vaccine
(swine flu) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Influenza A (H1N1) 2009 Monovalent Vaccine |
|
|
|
| allantoic fluid of chicken eggs, sucrose, beta-Propiolactone, sodium, taurodeoxycholate, phosphate buffered isotonic solution | sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, neomycin sulfate, polymyxin B, beta-propiolactone |
| Influenza A (H1N1) 2009 Monovalent Vaccine |
|
|
|
| ID Biomedical Corporation of Quebec |
| Jan. 2010 |
| allantoic cavity of embryonated hens' eggs, formaldehyde, sodium deoxycholate, phosphate-buffered saline solution | thimerosal, egg proteins, formaldehyde, sodium deoxycholate |
| Influenza A (H1N1) 2009 Monovalent Vaccine |
|
|
|
| specific pathogen-free (SPF) chicken eggs, sucrose, potassium phosphate | monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate |
| Influenza A (H1N1) 2009 Monovalent Vaccine |
|
|
|
| Sanofi Pasteur, Inc |
| Sep. 2009 |
| embryonated chicken eggs, formaldehyde, sucrose density solution, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate buffered isotonic chloride solution | gelatin, formaldehyde, polyethylene glycol p-isooctylphenyl ether, sucrose |
|
17. Influenza A (H5N1) Vaccine
(bird flu) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Influenza Virus Vaccine (H5N1) |
|
|
|
| ID Biomedical Corporation of Quebec |
| 2013 |
| phosphate buffered saline solution, allantoic cavity of embryonated hen's eggs, formaldehyde, sodium deoxycholate, DL-a-tocopherol, polysorbate 80 | thimerosal, squalene, DL-a-tocopherol, polysorbate 80, ovalbumin, formaldehyde, sodium deoxycholate |
| Influenza A (H1N1) 2009 Monovalent Vaccine |
|
|
|
| embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, nonionic surfactant, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate buffered isotonic sodium chloride solution | porcine gelatin, thimerosal, formaldehyde, Polyethylene Glycol p-isooctylphenyl Ether, sucrose |
|
18. Influenza Vaccine
(flu) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Influenza Virus Vaccine |
| Afluria (Trivalent) |
|
| Seqirus Pty. Ltd. |
| 2016-2017 |
| beta-propiolactone, sodium taurodeoxycholate, allantoic fluid of embryonated chicken eggs, sucrose density agent, phosphate buffered isotonic solution | thimerosal (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, ovalbumin, mercury, sodium, chloride, beta-propiolactone, sucrose |
|
*This vaccine has been discontinued. |
| Novartis Vaccines and Diagnostics, Inc. |
| Feb. 21, 2013 |
| kanamycin, neomycin sulfate, cetyltrimethylammonium bromide, allantoic cavity of embryonated hens' eggs | formaldehyde, egg protein, polysorbate 80, CTAB, neomycin, kanamycin |
| Influenza Vaccine, Adjuvanted |
| Fluad (Trivalent) |
|
| allantoic cavity of embryonated hen's eggs, MF59C.1 adjuvant (MF59), formaldehyde, cetyltrimethylammonium bromide (CTAB) | MF59C.1 adjuvant (squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate), neomycin, kanamycin, barium, egg proteins, formaldehyde, cetyl trimethylammonium bromide (CTAB) |
|
|
| GlaxoSmithKline Biologicals |
| 2016-2017 |
| embryonated chicken eggs, sodium phosphate-buffered isotonic sodium chloride solution, sodium deoxycholate, formaldehyde, linear sucrose density gradient solution (contains detergent) | octoxynol-10 (Triton X-100), a-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), gentamicin sulfate, ovalbumin, hydrocortisone, formaldehyde, sodium deoxycholate |
|
|
| GlaxoSmithKline Biologics |
| 2015-2016 |
| embryonated chicken eggs, linear sucrose density gradient solution (containing detergent), sodium deoxycholate, formaldehyde, sodium phosphate buffered isotonic sodium chloride solution | octoxynol-10 (Triton 272 X0100), a-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate |
| Influenza Vaccine |
| Flublok (Trivalent) |
|
| Protein Sciences Corporation |
| 2016-2017 |
| HA insect cell (fall armyworm, Spodoptera frugiperda) proteins, lipids, vitamins, amino acids, mineral salts, Triton X-100 | sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20 (Tween 20), host cell proteins, baculovirus, Triton X-100, host cell DNA |
|
|
| Seqiris, Inc. |
| May 23, 2016 |
| Madin Darby Canine Kidney (MDCK) cells, B-propiolactone, cetyltrimethylammonium bromide, phosphate buffered saline | MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, B-propiolactone |
|
|
| Madin Darby Canine Kidney (MDCK) cells, B-propiolactone, cetyltrimethylammonium bromide | MDCK cell protein, other cell proteins, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, B-propiolactone |
| Influenza Virus Vaccine |
| FluLaval(Quadrivalent) |
|
| ID Biomedical Corporation of Quebec |
| 2016-2017 |
| allantoic cavity of embryonated hens' eggs, formaldehyde, sodium deoxycholate | thimerosal, ovalbumin, formaldehyde, sodium deoxycholate, a-tocopheryl hydrogen succinate, polysorbate 80 |
| Influenza Virus Vaccine |
| FluLaval (Trivalent) |
|
| ID Biomedical Corporation of Quebec |
| 2015-2016 |
| allantoic cavity of embryonated hens' eggs, formaldehyde, sodium deoxycholate | phosphate-buffered saline solution, thimerosal (multi-dose vaccine only), ovalbumin, formaldehyde, sodium deoxycholate, a-tocopheryl hydrogen succinate, polysorbate 80 |
|
|
| SPF (specific pathogen-free) eggs, stabilizing buffer, sucrose, potassium phosphate | monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA) |
|
|
| Sequiris Vaccines, Ltd. |
| 2016-2017 |
| allantoic cavity of embryonated hens' eggs, neomycin, polymyxin, betapropiolactone, nonylphenol ethoxylate | phosphate-buffered saline, thimerosal, egg proteins, polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate |
|
|
| Sanofi Pasteur, Inc. |
| 2016-2017 |
| embryonated chicken eggs, Octylphenol Ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, linear sucrose density gradient solution | formaldehyde, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, gelatin (standard formulation only), thimerosal (standard dosage multi-dose vial only) |
|
| 19. Japanese Encephalitis Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Japanese Encephalitis Vaccine, Inactivated, Adsorbed |
| Ixiaro |
|
| Intercell Biomedical |
| 2016 |
| Vero cells, protamine sulfate, formaldehyde, aluminum hydroxide | formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell proteins, protamine sulphate |
| Japanese Encephalitis Vaccine, Inactivated |
| JE-Vax* |
*This vaccine has been discontinued. |
| Research Foundation for Microbial Diseases of Osaka University |
| Dec. 2005 |
| mice (brains are inoculated with the virus), phosphate-buffered saline, formaldehyde, 40% w/v sucrose | thimerosal, Sterile Water for Injection, gelatin, formaldehyde, v/v Polysorbate 80, mouse serum protein |
|
| 20. Measles Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
*This vaccine has been discontinued. |
| Merck &Co., Inc. |
| Feb. 2006 |
| chick embryo cell culture, buffered salt solution, vitamins, amino acides, fetal bovine serum, SPGA (sucrose, phosphate, glutamate, human albumin), neomycin | sorbitol, sodium phosphate, sucrose, sodium, chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, neomycin, other buffer and media ingredients |
|
21. Meningococcal Vaccine
(meningitis) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Meningococcal Group B Vaccine |
| Bexsero |
|
| Novartis Vaccines and Diagnostics |
| 2015 |
| factor H binding protein (fHbp), Outer Membrane Vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, Escherichia coli (E. coli), deoxycholate | kanamycin |
| Meningococcal (Serogroups A, C, Y and W-135)Polysaccharide Diphtheria Toxoid Conjugate Vaccine |
| MCV4-Menactra |
|
| Mueller Hinton agar, Watson Scherp media (containing casamino acid), formaldehyde, ammonium sulfate, modified culture medium (containing hydrolyzed casein) | formaldehyde, sodium phosphate buffered isotonic sodium chloride solution |
| Meningococcal Groups C and Y and Haemophilus b Tetanus Toxoid Conjugate Vaccine |
| MenHibrix |
|
| GlaxoSmithKline Biologicals |
| 2013 |
| semi-synthetic media, formaldehyde, sucrose, saline diluent, sterile saline solution | Tris (trometamol)-HCL, sucrose, formaldehyde, saline diluent |
| Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine |
| Menveo |
|
| Novartis Vaccines and Diagnostics, Inc. |
| Aug. 2013 |
| Franz Complete medium, formaldehyde, CY medium (contains yeast extracts and amino acids), purified polysaccharides, CRM197 protein | formaldehyde |
|
|
| Mueller Hinton casein agar, Watson Scherp casamino acid media | distilled water, thimerosal, polysaccharide from serogroups A, C, Y, and w-135, mercury, lactose |
|
|
| Wyeth Pharmaceuticals, Inc. |
| 2016 |
| E. coli, defined fermentation growth media, polysorbate 80(PS80) | polysorbate 80 (PS80), AI3+ (as AlPO4), mM histidine buffered saline |
|
22. MMR Vaccine
(measles, mumps, & rubella) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Measles, Mumps, and Rubella Virus Vaccine, Live |
| M-M-R-II |
|
| Merck and Co., Inc. |
| Oct. 2015 |
| chick embryo cell culture, WI-38 human diploid lung fibroblasts, Medium 199 (containing vitamins, amino acids, fetal bovine serum, SPGA (sucrose, phosphate, glutamate, recombinant human albumin), neomycin, Minimum Essential Medium (containing vitamins, amino acids, fetal bovine serum, recombinant human albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizer | sorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, other buffer and media ingredients, neomycin |
|
|
| Merck and Co., Inc. |
| Oct. 2015 |
| chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, bovine serum, recombinant human albumin | sucrose, hydrolyzed gelatin, urea (refrigerator stable formulation only), sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, components of MRC-5 cells (including DNA and protein), neomycin, bovine serum albumin, other buffer and media ingredients, sodium phosphate dibasic (frozen formulation only), potassium phosphate monobasic (frozen formulation only), potassium phosphate dibasic (frozen formulation only) |
|
23. Pneumococcal Vaccine
(pneumonia) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) |
| Prevnar* |
*This vaccine has been discontinued. |
| Wyeth Pharmaceuticals Inc. |
| Mar. 2009 |
| soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfate, saccharides | aluminum (as aluminum phosphate adjuvant) |
| Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein) |
| Prevnar 13 |
|
| Wyeth Pharmaceuticals Inc. |
| 2016 |
| soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfate, CRM 197 | polysorbate 80, succinate buffer, aluminum (as aluminum phosphate adjuvant) |
|
|
| Merck & Co., Inc. |
| May 2014 |
| -- | isotonic saline solution, phenol |
|
| 24. Polio Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Poliovirus Vaccine Inactivated (Monkey Kidney Cell) |
| IPOL |
|
| Vero cells, Eagle MEM modified medium, newborn calf serum, M-199 (without calf serum) | 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, calf bovine serum albumin |
|
| 25. Rabies Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Sanofi Pasteur, SA |
| Apr. 25, 2013 |
| MRC-5 cells, beta-propiolactone | human albumin, neomycin sulfate, phenol red indicator, beta-propiolactone |
|
|
| Novartis Vaccines and Diagnostics |
| Nov. 2013 |
| chicken fibroblasts, synthetic cell culture medium (with added human albumin), polygeline (processed bovine gelatin), antibiotics, B-propiolactone, sucrose density-gradient, buffered polygeline, potassium glutamate | polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, chicken ovalbumin, neomycin, chlortetracycline, amphotericin B, water for injection |
|
| 26. Rotavirus Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Rotavirus Vaccine, Live, Oral, Pentavalent |
| RotaTeq |
|
| Merck & Co., Inc. |
| June 2013 |
| Vero cells, buffered stabilizer, porcine-derived materials | sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, DNA for porcine circoviruses |
| Rotavirus Vaccine, Live, Oral |
| Rotarix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| Vero cells, porcine-derived materials, amino acids, dextran, Dulbecco's Modified Eagle Medium (sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, phenol red), sorbitol, sucrose | calcium carbonate, sterile water, xanthan, porcine cirrovirus type 1 |
|
| 27. Rubella Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
*This vaccine has been discontinued. |
| Merck & Co., Inc. |
| Feb. 2006 |
| WI-38 human diploid lung fibroblasts, Minimum Essential Medium (MEM; buffered salt solution (vitamins, amino acids, bovine serum), human serum albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizer | sorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, other buffer and media ingredients, neomycin |
|
| 28. Smallpox Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Smallpox (Vaccinia) Vaccine, Live |
| ACAM2000 |
|
| Sanofi Pasteur Biologics Co. |
| Dec. 2015 |
| Vero cells, human serum albumin, sodium chloride, mannitol, neomycin, polymyxin B, Dryvax | glycerin, phenol in Water for Injection |
|
29. TD Vaccine
(tetanus & diphtheria) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Tetanus and Diphtheria Toxoids Adsorbed For Adult Use |
| DECAVAC* |
*This vaccine has been discontinued. |
| Sanofi Pasteur, Inc. |
| Mar. 2011 |
| Mueller and Miller medium, peptone-based medium, extract of bovine muscle tissue, formaldehyde, ammonium sulfate | thimerosal, aluminum potassium sulfate adjuvant, formaldehyde |
| Tetanus and Diphtheria Toxoids Adsorbed For Adult Use |
| TENIVAC |
|
| Sanofi Pasteur, Ltd. |
| Apr. 2013 |
| modified Mueller-Miller casamino acid medium (without beef heart infusion), formaldehyde, ammonium sulfate, modified Mueller's growth medium, aluminum phosphate | aluminum phosphate, formaldehyde, sodium chloride, water for injection |
| Tetanus and Diphtheria Toxoids, Adsorbed |
| -- |
|
| modified Mueller's media (contains bovine extracts), formaldehyde, ammonium sulfate, aluminum phosphate | aluminum adjuvant, formaldehyde, thimerosal |
|
*This vaccine has been discontinued. |
| Sanofi Pasteur, Inc. |
| Dec. 2005 |
| peptone-based medium, formaldehyde, ammonium sulfate, physiological saline solution | thimerosal, formaldehyde |
| Tetanus Toxoid Adsorbed |
| --* |
*This vaccine has been discontinued. |
| Sanofi Pasteur, Inc. |
| July 2005 |
| peptone-based medium (contains extract ofbovine muscle tissue), formaldehyde, ammonium sulfate, aluminum potassium sulfate (alum) | thimerosal, physiological saline solution |
|
30. Tdap Vaccine
(tetanus, diphtheria, & pertussis) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
| Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed |
| Adacel |
|
| Sanofi Pasteur, Ltd. |
| 2015 |
| modified Stainer-Scholte medium (added casamino acid, dimethyl-beta-cyclodextrin), glutaraldehyde, formaldehyde, aluminum phosphate, modified Mueller-Miller casamino acid medium (without beef heart infusion), ammonium sulfate, 2-phenoxyethanol, water for injection | aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, water for injection |
| Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed |
| Boostrix |
|
| GlaxoSmithKline Biologicals |
| 2016 |
| modified Latham medium derived from bovine casein, Fenton medium (containing bovine extract), formaldehyde, modified Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide | aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80) |
|
| 31. Typhoid Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Sanofi Pasteur SA |
| Mar. 2014 |
| semi-synthetic medium, hexadecyltrimethylammonium bromide | formaldehyde, phenol, polydimethylsiloxane or fatty-acid ester-cased antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, sterile water for injection, vi polysaccharide |
| Typhoid Vaccine Live Oral Ty21a |
| Vivotif |
|
| Berna Biotech, Ltd. |
| Sep. 2013 |
| yeast extract, casein, dextrose, and galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearate | sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate |
|
32. Varicella Vaccine
(chickenpox) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Merck & Co., Inc. |
| Dec. 2012 |
| human embryonic lung cell cultures, embryonic guinea pig cell cultures, WI-38 human diploid cell cultures, MRC-5 human diploid cell cultures, sucrose, phosphate, glutamate, processed gelatin, urea (refrigerated vaccine only) | sucrose, hydrolyzed gelatin, urea (refrigerated vaccine only), sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum, sodium phosphate monobasic, EDTA, fetal bovine serum |
|
| 33. Yellow Fever Vaccine |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Sanofi Pasteur, Inc. |
| June 2016 |
| living avian leukosis virus-free (ALV-free) chicken embryos | sorbitol, gelatin, sterile diluent (sodium chloride) |
|
34. Zoster Vaccine
(shingles) |
| PROPER NAME |
COMMERCIAL NAME
(click for package insert) |
|
| MANUFACTURER |
| PACKAGE INSERT DATE |
| GROWTH MEDIUMS & PROCESS INGREDIENTS | VACCINE INGREDIENTS
(not in order of quantity; see package insert for quantities) |
|
|
| Merck & Co., Inc. |
| Feb. 2016 |
| -- | sucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum, urea (refrigerator stable only) |
 |
| II. GLOSSARY AND DETAILS FOR INGREDIENTS |
| Product | Possible Ingredients
(Ingredients depend on which modification is used.) |
| 2-Phenoxyethanol | 2-Phenoxyethanol is a glycol ether used as a preservative in vaccines. |
| Aluminum | Aluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully. |
| Bovine casein | A casein is a family of phosphoproteins commonly found in mammalian milk. 80% of the proteins in cow's milk are casein. |
| Bovine serum | Bovine "[s]erum is the centrifuged fluid component of either clotted or defibrinated whole blood. Bovine serum comes from blood taken from domestic cattle. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume."
"Bovine serum is a by-product of the meat industry. Bovine blood may be taken at the time of slaughter, from adult cattle, calves, very young calves or (when cows that are slaughtered are subsequently found to be pregnant) from bovine fetuses. It is also obtained from what are called 'donor' animals, which give blood more than once.
Blood is available from bovine fetuses only because a proportion of female animals that are slaughtered for meat for human consumption are found (often unexpectedly) to be pregnant.
Blood is available from very young calves because calves, especially males from dairy breeds, are often slaughtered soon, but not necessarily immediately, after birth because raising them will not be economically beneficial. Older animals are, of course, slaughtered for meat.
Only donor cattle are raised for the purpose of blood donation. Donor cattle are invariably kept in specialized, controlled herds. Blood is taken from these animals in a very similar way to that used for human blood donation.
Irrespective of whether blood is taken at slaughter or from donors, the age of the animal is an important consideration because it impacts the characteristics of the serum.
Bovine serum is categorised according to the age of the animal from which the blood was
collected as follows:
•'Fetal bovine serum' comes from fetuses
•'Newborn calf serum' comes from calves less than three weeks old
•'Calf serum' comes from calves aged between three weeks and 12 months
•'Adult bovine serum' comes from cattle older than 12 months
Serum processed from donor blood is termed 'donor bovine serum'. Donor animals can be up to three years old." |
| Chicken Eggs | Viruses can be grown in chicken eggs before being used in vaccinations. |
| CMRL-1969 | L-alanine, L-arginine (free base)b, L-aspartic acid, L-cysteine-HCL, L-cystine, L-glutamic acid-H20, L-glutamine, glycine, L-histidine (free base)b, L-hydroxyproline, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, p-aminobenzoic acid, ascorbic acid, d-biotin, calcium pantothenate, cholesterol, choline chloride, ethanol, folic acid, glutathione, i-inositol, menadione, nicotinamide, nicotinic acid, pyridoxal-HCL, pyridoxine-HCL, riboflavine, riboflavine-5-phosphate, sodium acetate-3H2O, thiamine-HCL, Tween 80, vitamin A acetate, vitamin D (calciferol), vitamin E (a-tocopherol phosphate), D-glucose, phenol red, sodium chloride, potassium chloride, calcium chloride, magnesium culphate heptahydrate, sodium phosphate dibasic, sodium dihydrogen phosphate, monopotassium phosphate, sodium bicarbonate, iron nitrate nonahydrate |
| Dulbecco's Modified Eagle's Serum | glucose, sodium bicarbonate, L-glutamine, pyridoxine HCl, pyridocal HCl, folic acid, phenol red, HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid), L-methionine, L-cystine, sodium phosphate mono-basic, sodium pyruvate, vitamins |
| Earle's Balanced Salt Medium | inorganic salts, D-glucose, phenol red, calcium, magnesium salts |
| Fenton Medium | bovine extract |
| Formaldehyde | Formaldehyde is used in vaccines to inactivate the virus so the person being inoculated does not contract the disease. |
| Human albumin | Human albumin is a blood plasma protein produced in the liver that, among other functions, transports hormones, fatty acids, and other compounds, and buffers pH. |
| Insect Cells | Cabbage moth and fall armyworm cells are used to grow viruses for vaccines. |
| Latham Medium | bovine casein |
| MDCK (Madin-Carby canine kidney cells) | cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle's Minimum Essential Medium with Earle's Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum |
| Mouse Brains | Live mice brains are inoculated with the Japanese encephalitis virus to grow the virus used in the vaccine. |
| MRC-5 | Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for "psychiatric reasons" in 1966 in the United Kingdom, Eagle's Basal Medium in Earle's balanced salt solution with bovine serum. |
| Mueller Hinton Agar | beef extract, acid hydrolysate of casein, starch, agar |
| Mueller-Miller Medium | glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution |
| Polysorbate 80 | Also called Tween 80, Alkest 80, or Canarcel 80 (brand names). Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients). |
| Porcine gelatin | Gelatin is used to protect viruses in vaccines from freeze-drying or heat and to stabilize vaccines so they stay stable. |
| Stainer-Scholte Liquid Medium | tris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, ascorbic acid, niacin, glutathione |
| Thimerosal | Thimerosal is an organomercury compound used as a preservative. |
| Vero Cells (African Green Monkey Cells) | cells derived from the kidney of a normal, adult African Green monkey in 1962 by Y. Yasumura and Y. Kawakita |
| WI-38 human diploid cells | Winstar Institute 38, human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States |
 |
III. SOURCES
Acumedia Manufacturers, "Mueller Hinton Agar (7101)," www.neogen.com, June 2011
Atlanta Biologicals, "Earle's Balanced Salt Solution (EBSS)," www.atlantabio.com, 2010
CDC, "Basics and Common Questions: Ingredients of Vaccines - Fact Sheet," www.cdc.gov, Feb. 22, 2011
FDA, "Vaccines Licensed for Immunization and Distribution in the US with Supporting Documents," www.fda.gov, Aug. 29, 2016
Health Protection Agency, "General Cell Collection: MDCK," www.hpacultures.org.uk, 2011
G.M. Healy, S. Teleki, A.V. Seefried, M.J. Walton, and H.G. Macmorine, "Improved Chemically Defined Basal Medium (CMRL-1969) for Primary Monkey Kidney and Human Diploid Cells," Applied and Environmental Microbiology, www.aem.asm.org, 1971
International Serum Industry Association, "FAQ," www.serumindustry.org/faq, 2013
Pontifical Academy for Life, "Moral Reflections on Vaccines Prepared From Cells Derived From Aborted Human Foetuses," www.immunize.org/concerns/vaticandocument.htm, June 9, 2005
Rebecca Sheets, "History and Characterization of the Vero Cell Line," www.fda.gov, May 12, 2000
Sigma-Aldrich, "DMEM," www.sigmaaldrich.com, 2013
Alison Weiss, "The Genus Bordetella," The Prokaryotes: A Handbook on the Biology of Bacteria," Ed. Martin M. Dworkin, Stanley Falkow, Karl-Heinz Schleifer, and Erko Stackebrandt, 2006.
World Health Organization, "Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production," www.who.int, Sep. 3, 1999
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